7. PREDICT: European harmonised large scale patient-oriented PATHOgenesis research Studies in response to severe ID outbreaks –workpackage 7

European Diagnostic Platform for REsearch and support on Diagnostics for Infectious disease Clinical Trails.

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Key Objectives

This study aims to:

  1. establish a European PREPARE laboratory facility that can provide diagnostic capacity to support the clinical studies in PRACTICE, and to establish the PREPARE Biobank for storing and distributing well-characterised strains and clinical specimens that come from existing collections and prospective sampling in PRACTICE studies;
  2. validate rapid diagnostic tests on homogenous platforms such as Biocartis Idylla and DMAT for viruses and bacteria with epidemic potential, including multi-resistant organisms, and to deploy those techniques for the pathogens with epidemic potential studied in WP 3-4 or in response to new epidemic strains;
  3. develop and standardise bacterial Whole Genome Mapping to enable real-time, high resolution outbreak management, and to deploy available new viromics technologies for viral epidemic identification and follow-up;
  4. develop generic SOPs for harmonisation of laboratory-based (in-house) pathogen detection protocols; to conduct external quality assessment for their evaluation; and to incorporate those generic SOPs in clinical trials;
  5. develop standardised multiplex serological tests for potentially epidemic viral pathogens;
  6. perform ad-hoc development and deployment of detection assays in case of epidemics, including (i) provision of positive controls, (ii) follow-up of implementation by questionnaires and EQA; (iii) second-generation test deployment (ready-to-use tests) by involvement of industry.


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  • Al-Gethamy M, Corman VM, Hussain R, Al-Tawfiq JA, Drosten C, Memish ZA. A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker. Clin Infect Dis. 2015;60(6):973-4 doi: 10.1093/cid/ciu1135
  • Seong MW, Kim SY, Corman VM, Kim TS, Cho SI, Kim MJ, Lee SJ, Lee J-S, Seo SH, Ahn JS, Yu BS, Park N, Oh M-d, Park WB, Lee JY, Kim G, Joh JS, Jeong I, Kim EC, Drosten C, Park SS. Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus, South Korea,2015. Emerg Infect Dis. 2016;22(2):327-30. doi: 10.3201/eid2202.151700
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  • Cleton NB, Reusken CB, Wagenaar JF, van der Vaart EE, Reimerink J, van der Eijk AA, Koopman MP. Syndromic Approach to Arboviral Diagnostics for Global Travelers as a Basis for Infectious Disease Surveillance. PLoS Negl Trop Dis. 2015;9(9):e0004073. doi: 10.1371/journal.pntd.0004073
  • Pas SD, Patel P, Reusken C, Domingo C, Corman VM, Drosten C, Dijkman R, Thiel V, Nowotny N, Koopmans MP, Niedrig M. First international external quality assessment of molecular diagnostics for Mers-CoV. J Clin Virol. 2015;69:81-5. doi: 10.1016/j.jcv.2015.05.022
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Team members

Greet Ieven Coördinator
Marion Koopmans Liaison to WP3
Christian Drosten Team member
Alex van BELKUM Team member
Geert Maertens Team member

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Herman Goossens


Deputy Coordinator:

Menno de Jong




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