The European clinical research framework of PREPARE consists of three interconnected platforms – PATHOS, PRACTICE and PREDICT, supported by a common ICT infrastructure – CRISP – and strengthened by a comprehensive training and education effort – CREATE. Together they provide the framework for rapid, harmonised, large–scale and fit-for-purpose clinical research in response to any severe ID outbreak within Europe (defined as “any severe infectious outbreak with a pandemic potential or significant risk of major damage to health and socio-economics in the EU”).