A second preparedness exercise to test and refine PREPARE’s Outbreak response capability took place on 3 October 2017 in Brussels, Belgium. The workshop was an opportunity for PREPARE partners to review and further develop PREPARE’s Outbreak Clinical Research Modes planning which details how PREPARE responds to severe infectious disease (ID) outbreaks that present a threat to Europe. The PREPARE Core Group, led by Herman Goossens, co-ordinated the workshop and 28 participants attended representing a wide range of stakeholders that included DG Research, DG Sante and ECDC.