PRACTICE is the central clinical research platform of PREPARE. It harbours the clinically oriented activities encompassing five main studies that will be conducted during the inter-epidemic periods.
The EARL study is aimed at identifying and implementing solutions to key structural (ethical, administrative, regulatory and logistical) bottlenecks as well as behavioural and cultural (BC) barriers to the rapid implementation of large multi-site clinical studies in Europe in response to severe ID outbreaks.
The PRIME study is the clinical counterpart of the EARL study and it aims at mapping the pan-European clinical management of severe IDs and develop harmonised clinical case definitions, guidelines and pre-approved protocols for large multi-site clinical studies in Europe in response to severe ID outbreaks.
European Multi-centre standardised observational and natural history clinical data study in hospitalised and community patients (children and adults) with acute respiratory infection, severe illness caused by central nervous system infections and undifferentiated fever, or hemorrhagic fever.
European Multi-centre open, adaptive, randomised interventional trial on Influenza-Like-Illness (ILI) in Primary Care (PC).
European adaptive randomised controlled trial to improve survival in hospitalised patients with Severe Acute Respiratory Infection (SARI).
Menno de Jong